A Flexible Estimating Equations Approach for Mapping Function-Valued Traits
نویسندگان
چکیده
منابع مشابه
A flexible estimating equations approach for mapping function-valued traits.
In genetic studies, many interesting traits, including growth curves and skeletal shape, have temporal or spatial structure. They are better treated as curves or function-valued traits. Identification of genetic loci contributing to such traits is facilitated by specialized methods that explicitly address the function-valued nature of the data. Current methods for mapping function-valued traits...
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Genome-wide association studies commonly examine one trait at a time. Occasionally they examine several related traits with the hope of increasing power; in such a setting, the traits are not generally smoothly varying in any way such as time or space. However, for function-valued traits, the trait is often smoothly varying along the axis of interest, such as space or time. For instance, in the...
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The genetic analysis of characters that are best considered as functions of some independent and continuous variable, such as age, can be a complicated matter, and a simple and efficient procedure is desirable. Three methods are common in the literature: random regression, orthogonal polynomial approximation, and character process models. The goals of this article are (i) to clarify the relatio...
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ژورنال
عنوان ژورنال: Genetics
سال: 2011
ISSN: 0016-6731,1943-2631
DOI: 10.1534/genetics.111.129221